Discover and share the best of the web!
Learn more about Digg by taking the tour.
New Drug Can Make You a SuperHuman
nytimes.com — Resveratrol has been shown, in mice, to double their endurance They also have a reduced heart rate and energy-charged muscles, just as trained athletes do, according to an article published online in Cell. “Resveratrol makes you look like a trained athlete without the training,” author Dr. Auwerx said in an interview.
Tanbo- 1180 diggs
- digg it
- wimax, on 10/12/2007, -5/+98geez! next thing you know, they'll be coming out with drugs to give you firmer longer erections!
- mousy, on 10/12/2007, -47/+15 * Viagra does the trick.
- AllnightChemist, on 10/12/2007, -3/+60"...longer erections"?
Now THAT would sell... - neoform, on 10/12/2007, -13/+5Nice, now we can expect a form of Eugenics when it comes to professional athletes! Just what we needed.
- shreveyboy, on 10/12/2007, -17/+12Cool! How long until the War on Drugs bans this one!??!?
- zachblume, on 10/12/2007, -0/+29Holy CRAP, is it just me, or does this remind anyone of Dune? The spice extends your life.
- brstilson, on 10/12/2007, -2/+32I would hold out for thicker erections.
Poking at the cervix but not touching the sides won't score you many points. - xtmno3, on 10/12/2007, -0/+37Stimpacks baby!
*injection noise* Oh yeah! - billlyboobs34, on 10/12/2007, -19/+1Touching the cervix during sex hurts a girl really bad.. I have this problem all the time.
- Splizxer, on 10/12/2007, -0/+8Just take a few buffouts, watch out as they are highly addictive and cause reduced intelligence.
- saichele, on 10/12/2007, -3/+2It's my understanding, from various conversations with female friends, that 'thicker' is indeed preferable to 'longer'.
- billlyboobs34, on 10/12/2007, -9/+3So you have no first hand experience?
- sardion2000, on 10/12/2007, -1/+5@ neoform, do you even know what Eugenics means? It's breeding a superior race through the eradication of undesirable elements through either sterilization or euthanization.
This is far from it(unless you're worried we're creating a slave race of super-miceys that is. ;) )
People should have the ability to choose freely whether they want to modify their own body or not. - josegutz, on 10/12/2007, -1/+5"Resverotol"
Commericial intro:
{{{{{People soaking in two old bathtubs side by side at the edge of a cliff drinking Corvasieur and smoking Cigars}}}}} (Music playing in background) {{{{DOOOOoooo WHatHCA WHAAANNA DOOO Ooo OOOO hhoooo hoooooo!}}}
Announcer with deep LaFountaine voice {{{{Feeling inadequate about yourself? Need that extra UMPph to get you up and alive again? Maybe it's time for a new day...Talk to your doctor about Rosveratol, and tell him that you've had enough of everyones ***** today!}}}} {{{DOOOOOoooooooooooo ooo oooo oooooo WHatcha Whatcha Wann Deeeewwwwwwwwwwwwwwww}}}} {{{{DO what you want, because nobody is gonna stop you now!!}}}}} Rosveratol... May cause dizziness, rectal seapage, vomiting, and cramps. Also be sure to tell you doctor if an erection lasts longer than 12 hours.
Rosveratol.. isn't it time you Do whatcha Want! - billlyboobs34, on 10/12/2007, -4/+3Do what you wanna do...In living color?
- neoform, on 10/12/2007, -5/+2sardion2000:
A) i said "a form of eugenics"
B) Eugenics applies here, since what would end up happening is athletes that _don't_ take this pill will be basically look down on since they're not achieving all that they could..
sucks for anyone who doesn't want to 'enhance' their bodies with pills.. - jiggleflop, on 10/12/2007, -0/+1I read about this stuff six years ago.
They didnt claim all these benefits, but just the anti-cancer properties was enough for me.
I tried drinking a glass of red wine every day, but I didn't like the heart burn.
I ate a cup a day of blueberries for a while, but that got too hard to swallow.
I started on the resveratrol caplets three months ago, 40mg(one capsule) in the morning and one before bed.
My two bulging vertibrae in my back quit hurting, and my arthritis cleared up.
I'm not taking any other sup. or meds, so I think its the resveratrol. - TopherT, on 10/12/2007, -0/+3@neoform you are a moron.
http://en.wikipedia.org/wiki/Eugenics - shokk, on 10/12/2007, -2/+4The candle that burns twice as bright burns half as long.
- JEmerson, on 10/12/2007, -2/+1"The candle that burns twice as bright burns half as long."
For those of us not made of wax, however, it's looking pretty good. Thumbs up to you for the bladerunner quote however, while a thumbs down to the article for not going into enough detail.
- KyleRayner, on 10/12/2007, -1/+41Its about time they perfected the Super Soldier Serum!
- vertinox, on 10/12/2007, -1/+26I'm pretty sure the side effects are insanity and desire to murder young teenagers making out in cars out in remote places.
- MiddleGirth, on 10/12/2007, -2/+30Isn't this how the Green Goblin got started?
- contradictator, on 10/12/2007, -1/+13A young soldier named Steve Rogers has stepped up to test the serum. Will it work? Only time will tell...
When reached for questions, Professor Banner refused to comment. - Nistavar, on 10/12/2007, -5/+1Steroids...?!?
- blackkbot, on 10/12/2007, -1/+4"I'm pretty sure the side effects are insanity and desire to murder young teenagers making out in cars out in remote places."
Sign me up!!
- banderbe, on 10/12/2007, -7/+39In other news, mice taking part in a new drug study drop dead twice as soon as mice who didn't participate.
- matthewaaron, on 10/12/2007, -1/+21Hopefully... What if they got loose... They'd be twice as hard to catch!
- neoform, on 10/12/2007, -2/+16Burn twice as bright, but for half as long.
- NanoStuff, on 10/12/2007, -0/+24If you read the article, they live longer. Resveratrol has been shown to extend the lifespan in all species tested thus far.
- MrESaulved, on 10/12/2007, -2/+19@matthewaaron
+1 for the only instance on the internets where the word 'loose' has been correctly applied. Bless you. - billlyboobs34, on 10/12/2007, -7/+2I see loose on the time on porn sites... oh wait that's only 1% of the internet.
- cdlavalle, on 10/12/2007, -1/+29"also been reported to extend the lifespan of mice."
Is there nothing this wonder-drug can't do? I can't wait to visit the Resveratrol kiosk in the mall!- badave, on 10/12/2007, -1/+14I've been reading a lot about Resveratrol lately and it really does seem to be that kind of "wonderdrug" that they would have in a mall. But it doesn't simply come from anywhere - it is THE chemical that was found in red wine that gives health benefits, such as decreased incidence of heart disease, to people who drink it.
Problem is, no one really knows if there are negative longterm effects or the proper "dosing" for it. - unibomber999, on 10/12/2007, -4/+86***** baby boomers are never going to die.
- florin, on 10/12/2007, -0/+9The kiosk is here:
http://www.t-nation.com/readTopic.do?id=1158493
Sure, they use it for bodybuilding purposes because it blocks the aromatization of testosterone to estrogen (therefore leading to higher levels of testosterone), but still it's pure resveratrol so it will work according to the studies. - Narrator, on 10/12/2007, -0/+18Are there negative long term effects? In mice it increases their lifespan. The negative long-term effect of NOT taking it seems to be death.
- jguy584, on 10/12/2007, -6/+3There are definitely going to be some nasty side effects from this drug, nothing can be all on the good side of spectrum. People are gonna take it for a few months and then realize that their bone density has decreased 75% or something else along those lines.
- glmory, on 10/12/2007, -0/+5"There are definitely going to be some nasty side effects from this drug, nothing can be all on the good side of spectrum. People are gonna take it for a few months and then realize that their bone density has decreased 75% or something else along those lines."
While this cannot get ruled out, they found this chemical while searching for chemicals to prolong lifespan. It has been noted in just about every animal studied calorie restriction increased life-span. This molecule seems to activate these same genes. If true the side effects are unlikely to be anywhere near the benefits. - napier, on 10/12/2007, -0/+4Red, red wine
make me feel so fine
keeps me BUFF, all of de time
- badave, on 10/12/2007, -1/+14I've been reading a lot about Resveratrol lately and it really does seem to be that kind of "wonderdrug" that they would have in a mall. But it doesn't simply come from anywhere - it is THE chemical that was found in red wine that gives health benefits, such as decreased incidence of heart disease, to people who drink it.
- Sarev0k, on 10/12/2007, -0/+55Side effects include: minor insanity, delusions of grander and the urge to terrorize your home town dressed as the green goblin
- vermin, on 10/12/2007, -2/+19lol, in all seriousness though, you just know there's gonna be some hardcore side-effects. It just seems too good to be true.
- sixspeed, on 10/12/2007, -8/+8Isn't that Delusions of Grandeur?
- Jwoey, on 10/12/2007, -4/+18he misspelled a very uncommon word, give'm a break.
- kevindoc, on 10/12/2007, -0/+11http://en.wikipedia.org/wiki/Resveratrol
"Adverse Effects and Unknowns
While the health benefits of resveratrol seem promising, one study has found that it stimulates the growth of human breast cancer cells, possibly because of resveratrol's chemical structure, which is similar to a phytoestrogen." - Ratteler, on 10/12/2007, -0/+6Immortality without titties!!! NOOOOOOOOOOOOOOOO!!!!!!!!!!
- KiSA, on 10/12/2007, -13/+3wow, as if steroids have never existed before!
- chubbymidget, on 10/12/2007, -0/+72Mice get all the cool stuff.
- SundayTrain, on 10/12/2007, -4/+20Score one again for red wine! Thank you Jesus :-|
- zachblume, on 10/12/2007, -0/+6You would need to drink like over 50 glasses of red wine a day to get the dosage that these mice were getting. So no, red wine won't do anything even close to this, but may help you a little (I beleive some studies have shown over long periods of time it is good for you)
- vandread, on 10/12/2007, -0/+8only 50? Ok! I have a new goal for the weekend! drink 150 glasses of red wine!
- cmearns, on 10/12/2007, -0/+3Actually - if you read the wiki, it is 50 BOTTLES not glasses. I don't care who you are, that much red wine CAN'T be good for you!
- Hegemony, on 10/12/2007, -7/+5Their slogan:
"Resveratrol... it's highly addictive!"
I don't know that it is. But you know... it can't be that clearcut. There is bound to be a downside.- elShaggy, on 10/12/2007, -2/+13...and we'll charge you out the ass for it.
- LSDrago, on 10/12/2007, -0/+7excellent futurama reference
- zachblume, on 10/12/2007, -0/+1Well it sure will be damn addictive from the psychological aspect of things, I mean cigarettes are only physically addictive 96 hours after you stop, but many people still go back after that, wanting that "relaxed" feeling they had.
Cravings for doubled endurance? - billlyboobs34, on 10/12/2007, -0/+1"Cravings for doubled endurance?"
You know very well the women would love this..
- cyn0sure, on 10/12/2007, -1/+13We preferred to be called Uber Mensch
Everything sounds cooler in German - ALoserIsYou, on 10/12/2007, -7/+2captain america
- flamingmb, on 10/12/2007, -5/+7And it will shrink your nuts too!
- billlyboobs34, on 10/12/2007, -0/+5That's steroids ... any by the way testosterone makes me really f*in' horny. I'm about ready to hump a fricken light pole.
- vandread, on 10/12/2007, -1/+6It says it specifically won't shrink your nutz
- flamingmb, on 10/12/2007, -0/+1it was a joke....
dont get all scientific, god damnit.
- gwalbridge, on 10/12/2007, -9/+43ENTIRE ARTICLE (because nytimes.com login blows ass)
Given that some athletes will take almost anything to gain a one percent edge in performance, what might they do for a 100 percent improvement? That temptation is made somewhat more real by a report today in a leading journal about a drug that doubles the physical endurance of mice running on treadmills. And it could only be more tempting, because the drug in question has also been reported to extend the lifespan of mice.
An ordinary lab mouse will run about one kilometer — five-eights of a mile — on a treadmill before collapsing from exhaustion. But mice given resveratrol, a minor component of red wine and other foods, run twice as far.
They also have a reduced heart rate and energy-charged muscles, just as trained athletes do, according to an article published online in Cell by Johan Auwerx and his colleagues at the Institute of Genetics and Molecular and Cellular Biology in Illkirch, France.
“Resveratrol makes you look like a trained athlete without the training,” Dr. Auwerx (pronounced OH-wer-ix”) said in an interview.
He and his colleagues said the same mechanism seems likely to operate in humans, based on their analysis, in a group of Finnish subjects, of the gene that is influenced by the drug.
Their rationale for testing resveratrol was evidence obtained three years ago that it could activate a genetic mechanism known to protect mice against the degenerative diseases of aging and to prolong their lifespan by 30 percent.
Dr. Auwerx, whose interest is in the genetic control of metabolism, decided to see if resveratrol would offset the effects of a high-fat diet, specifically the metabolic disturbances, known as metabolic syndrome, that are the precursors of diabetes and obesity.
In his report, he and his colleagues say that very large doses of resveratrol protected mice from gaining weight and from developing metabolic syndrome.
Dr. Auwerx attributes this change in large part to the significantly increased number of mitochondria he detected in the muscle cells of treated mice.
Mitochondria are the organelles within the body’s cells that generate energy. With increased mitochondria, the treated mice were able to burn off more fat and thus avoid weight gain and decreased sensitivity to insulin, Dr. Auwerx said. He found that their muscle fibers had been remodeled by the drug into the type more prevalent in trained human athletes.
Dr. Ronald M. Evans, a leading expert on the hormonal control of metabolism at the Salk Institute, said that the report by Dr. Auwerx’s team had “shown very convincingly that resveratrol improves mitochondrial function” and fends off metabolic disease.
Dr. Evans described the study as “very important, because it is rare that we identify orally active molecules, especially natural molecules, that have such a broad-based, positive effect on a problem as widespread in society as metabolic disease.”
Dr. Ronald Kahn, director of the Joslin Diabetes Center in Boston, said the research would focus attention on the sirtuins, a recently discovered group of enzymes that resveratrol is believed to affect. Noting that he is a scientific advisor to Sirtris, a company developing drugs that activate the sirtuins, Dr. Kahn said, “Certainly, drugs that act on this class of proteins have the potential to have major effects on human disease.”
Dr. Auwerx’s study complements one published earlier this month by Dr. David Sinclair of the Harvard Medical School, who found that much more moderate doses of resveratrol protected mice from the metabolic effects of a high-calorie diet. Though his mice did not lose weight, they lived far longer than undosed mice that were fed the same high-calorie diet.
The two studies were started and performed independently, Dr. Auwerx said, though he obtained supplies of resveratrol from Sirtris, which was co-founded by Dr. Sinclair, and he has become a scientific advisor to the company.
A drug that prolongs life, averts degenerative disease and, on top of all that, makes you into a champion athlete — at least if you are a mouse — sounds almost too good to be true.
Dr. Christoph Westphal, Sirtris’s chief executive, replied to this objection with a question: “Is it too good to be true that when you are young you get no disease?”
He believes that activation of the sirtuins is what keeps the body healthy in youth, but that these enzymes become less powerful with age, exposing the body to degenerative disease. That is the process that he says is reversed by resveratrol and, he hopes, by the more powerful sirtuin-activator drugs that his company is developing, though many years of clinical trials will still be needed to demonstrate whether they work and are safe to use.
The developing buzz over sirtuin activators has captivated some scientists who do research on the aging process, several of whom are already taking resveratrol themselves. Dr. Sinclair has said that he has been swallowing resveratrol capsules for three years, and that his parents and half his lab staff do the same.
So does Dr. Tomas Prolla at the University of Wisconsin. “The fact that investigators in the field are taking it is a good sign there is something there,” he said.
But many others believe taking the drug now is premature, including Dr. Leonard Guarente of M.I.T. whose 15-year study of the sirtuins laid the basis for the field of study. It was after working in Dr. Guarente’s lab as a postdoctoral student that Dr. Sinclair found in 2003 that resveratrol was a sirtuin activator.
Though resveratrol has long been known to be a component red wine and other foods, it is present there in only minuscule amounts, compared with the very large doses used in experiments. Dr. Sinclair dosed his mice daily with 22 milligrams of resveratrol for each kilogram of weight, and Dr. Auwerx used up to 400 milligrams. No one could drink enough red wine to obtain such doses.
Resveratrol is now available in capsules that contain extracts of red wine and giant knotweed, a plant found in China. One manufacturer of such capsules is Longevinex, whose president, Bill Sardi, said today that demand for the product had increased by a factor of 2400 since Nov. 1. But even Longevinex’s capsules, which at present contain 40 milligrams of resveratrol each, would have to be gulped in almost impossible quantities for a human to obtain doses equivalent to those used in mice. “It’s like eating a whole bottle of Tums every day,” Dr. Evans said.
Whether much lower doses would benefit athletic performance is not clear, Dr. Evans said. And higher doses may not be as safe as the lower doses found now in foods and “nutraceuticals” like the extract capsules.
Besides these uncertainties over what a safe and effective dose of resveratrol might be, the science underlying the field is still in full flux. Many central details are still unclear. The principal theory developed by Dr. Guarente and others is that the sirtuins somehow sense the level of energy expenditure in living cells and switch the body’s resources from reproduction to tissue maintenance when food is low.
This is an ancient strategy, Dr. Guarente believes, that allows an organism to live through famines and postpone breeding until good times return. The switch to tissue maintenance involves specific action to stave off the major degenerative diseases of aging, such as cancer, diabetes, heart disease and neurodegeneration.
Though resveratrol is in the spotlight, the central focus of researchers is on how the sirtuins are activated and what they do. One serious uncertainty is whether, in the mouse experiments, resverattrol in fact acted through the sirtuins or by some other unknown mechanism. In the latter case, Dr. Sinclair’s and Dr. Auwerx’s mouse experiments would offer less support to the sirtuin theory.
Dr. Auwerx cites evidence that resveratrol does activate sirtuin, but Dr. Evans said the case was not yet fully convincing.
Dr. Bruce Spiegelman, a Harvard Medical School expert on fat metabolism, said Dr. Auwerx’s paper was “pretty good.” Dr. Auwerx believes resveratrol activates sirtuin, which in turn activates a factor known as PGC1-alpha in a manner first described by Dr. Spiegelman and his colleagues last year. Subsequent actions by PGC1-alpha then stimulate cells to produce more mitochondria.
Increased energy production by mitochondria generates potentially dangerous reactive chemicals that are known to damage cells. So it has long been puzzling that exercise, in which energy is expended, is good for health, not bad.
Dr. Auwerx noted that Dr. Spiegelman showed in a report in the journal Cell last month that PGC1-alpha not only increases mitochondria, but at the same time generates chemicals that detoxify the energy by-products. - Langford, on 10/12/2007, -7/+1So what happens when you stop taking this drug? Do you become as weak as a little girl, or just drop dead?
- ShooterMcGavin, on 10/12/2007, -8/+3...Yeah... its called PCP.
- DanteDefiance, on 10/12/2007, -2/+12Oh man I can't wait to hear what the side effects on this one are.
- billlyboobs34, on 10/12/2007, -0/+4Probably about the same sides as say vitamin C
- Threnody, on 10/12/2007, -6/+8People will start using this as a club drug in 5, 4, 3....
- lunasunshine, on 10/12/2007, -0/+0half life is only 14mins.
- thefutureisours, on 10/12/2007, -50/+3Mitochondria? Marked as inaccurate as this is a term used in the Star Wars Phantom Menace. Sorry geeks, there is no secret chemical to give you force powers.
- blork1, on 10/12/2007, -0/+24That's midichlorians, 'tard.
- gwalbridge, on 10/12/2007, -0/+9http://en.wikipedia.org/wiki/Mitochondrion
- riverrunner, on 10/12/2007, -1/+13I think you are thinking of midoclorians. For those you need to take Jedieratrol
- Black913Hole, on 10/12/2007, -0/+14Midichlorians? something like that was in Star Wars, not mitochondria. Did you take high school biology yet?
--edit- good to see im not the only one. - armbar, on 10/12/2007, -0/+15Apparently you haven't been through basic cell biology. Mitochondria convert food to energy.
http://en.wikipedia.org/wiki/Mitochondria
Edit: I guess a few other people think you're retarded too. - cyn0sure, on 10/12/2007, -10/+9This, folks, is exactly what happens when you get a liberal arts degree.
- Wizardo55, on 10/12/2007, -2/+9Minus Digg for idiot.
- Molly, on 10/12/2007, -0/+6Oh god,
wasn't this the prolog for Parasite Eve?
BE AFRAID! FEAR THE MIDOCONDRIA!!!!
(PE pwns RE 100%) - MiddleGirth, on 10/12/2007, -9/+2"Apparently you haven't been through basic cell biology. Mitochondria convert food to energy.
http://en.wikipedia.org/wiki/Mitochondria
Edit: I guess a few other people think you're retarded too."
To be fair I graduated about 10 years ago and this is the first time Mitochondria has come into a conversation. How useful was that to learn? - DanteDefiance, on 10/12/2007, -3/+8@thefutureisours
You are the biggest jack ass I have ever seen on digg. How the ***** did you learn to use a computer? - armbar, on 10/12/2007, -0/+10MiddleGirth, I learned about this stuff in 6th grade and 9th grade, which were 11 years and 8 years ago, respectively. No, it doesn't come up in daily conversations, but I don't think I'd confuse it with The Force, either.
- zephc, on 10/12/2007, -1/+4U.S. school science curriculum FTL!
- shatters, on 10/12/2007, -2/+1Wow, star wars geeks might be little harsh when someone gets their star wars facts wrong.
- danny25, on 10/12/2007, -3/+3Myostatin seems to have similar effects on mice.
http://en.wikipedia.org/wiki/Myostatin - macrossone, on 10/12/2007, -6/+2Yeah, It's called crack.
- whipnet, on 10/12/2007, -5/+2The U.S. military has had superhumans jumping out of airplanes without parachutes for years. http://ufo.whipnet.org/xdocs/montauk.superman/
*remove tongue from cheek*
*- billblaskey, on 10/12/2007, -3/+9from the article mentioned above:
"If you ever took the time to notice, the male penis is shaped like an antennae. This is obviously done a for reason, and the reason is that the spirit is also sent out through the penis during the ejaculation.
This is the reason why "test tube" babies are born without a sole. As they were only conceived with the part of us that makes up the body, and as the insertion of the spirit was not part of the conception, this person is born without a soul (since there was no physical transfer)."
lmao - lbeaty1981, on 10/12/2007, -0/+19"This is the reason why "test tube" babies are born without a sole."
Wow, those poor babies. It's gotta be rough walking around without any bottoms to your feet... - vandread, on 10/12/2007, -0/+11Holy *****, so every time I bust one out I'm releasing my soul? Damn I must not have much of a soul left.
- billlyboobs34, on 10/12/2007, -1/+1Save up for a few days and you will broadcast as much soul as a porn star...
- Canthros, on 10/12/2007, -2/+2Branch water and grain alcohol for me, thanks.
- billblaskey, on 10/12/2007, -3/+9from the article mentioned above:
- whipnet, on 10/12/2007, -9/+1^^^
- lonnieh, on 10/12/2007, -0/+1vvv
- Narrator, on 10/12/2007, -5/+10All you guys who think that because it's good that it must have horrible side effects, like it's the second law of thermodynamics, have been brain washed by anti-illegal drugs education.
- jimmiss, on 10/12/2007, -3/+6This type of drug will be reserved for rich and famous people only. Us lowely serfs will have to live as usual, while people like Britney Spears and Steve Jobs get super heath and longevity.
- CrankyHippo, on 10/12/2007, -1/+4Sounds too good to be true... now if the mice turn into "zombie mice", then i'll believe it
- Pissoff, on 10/12/2007, -1/+5It is available now in much smaller doses, you can buy it from several online retailers including the Longevinex® company. http://www.longevinex.com
It's not very expensive at all. Good luck taking an entire bottle every day for a week to obtain the super human doses though! And enjoy your breast cancer, which some studies have suggest is a potential side effect.- Pissoff, on 10/12/2007, -0/+8You would need to consume 500mg per 50 pounds to get the same dose given to the mice.
If you are 200 pounds, that is 2000mg. Each capsule sold by Longevix contains about 15 mg so you would need to consume about 135 capsules. Each bottle contains 30 capsules @ $35/per. 4.5 bottles per dose. - Lahonda, on 10/12/2007, -1/+10Those little mice must be talking by now!
Pass the cheese, bitch! - Pissoff, on 10/12/2007, -1/+4Oooh on the other hand there is this company:
http://www.wholehealthproducts.com/wholehealthproducts/index.cfm?fuseaction=customer.landing_resveratrol
160mg of Resveratrol per dose, 30 doses per bottle @ $13.32 per bottle.
You could get a huge intake of 1600mg and get 3 doses per bottle if they are really putting 160mg of Resveratrol in 2 pills. - jasoninoakland, on 10/12/2007, -1/+2Keep in mind that that 160mg is really only 30% resveratrol, or 48mg. The rest, I guess, is just the other stuff in grapeskins.
For 2000mg, then, you would need about 42 doses, or about $15. A day.
Keep in mind that the amount given to the mice is arbitrarily chosen by the researchers. It's not as if you miraculously get health benefits by consuming that much and no less. - billlyboobs34, on 10/12/2007, -1/+2This stuff oxidizes too fast. Don't buy the supplements, they are a waste of money and will go bad (assuming they are not bad before you get them)..
- noisebleed, on 10/12/2007, -0/+2@billlyboobs34: It's a valid concern, but here are a couple of studies that refute the claim:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=16579722
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=10051967
From the first, "Recent reports allege their lack of stability at ambient conditions ... Chromatographic analysis did not detect any instability, thus disproving the claims to the opposite. No storage precautions are necessary for these nutritional supplements." - Mulo, on 10/12/2007, -0/+1Our friends the FDA publish guidelines for converting animal test species dosages into the human equivalents. Check out:
http://www.fda.gov/cber/gdlns/dose.htm#v
see "Conversion of Animal Doses to Human Equivalent Doses (HED) Based on Body Surface Area" (table 1)
it appears the there is a sliding decreasing ratio.HED = animal dose in mg/kg x (animal weight in kg/human weight in kg)^0.33.
I think the equivalent dose for a (60 Kg) human would be 240mg. (someone double check)
Also not just any Resveratrol will do, it needs to be TRANS-Resveratrol. A non oxidized form of the "suppliment".
- Pissoff, on 10/12/2007, -0/+8You would need to consume 500mg per 50 pounds to get the same dose given to the mice.
- btgoss, on 10/12/2007, -2/+8Khaaaaaaaaaannnnnnnn!!!!!!
- Lahonda, on 10/12/2007, -1/+6So, the way I see it, we'll be a nation of fat-asses with lots of stamina and live longer. Starbucks and McDonalds will be thrilled about this!
Chomp, chomp- academician, on 10/12/2007, -1/+2The drug was originally researched because of its possible effect of speeding up the metabolism and off-setting the effects of a high-fat diet. So, Starbucks and McDonalds may indeed be thrilled - but if this is true, then we might not be "a nation of fat-asses".
- megatron, on 10/12/2007, -1/+11Who needs this when we have alcohol?
- rocjoe71, on 10/12/2007, -0/+23...Resveratrol lets you run a little longer/faster? PFFT!
After 8 or 9 beers I am ten-foot-tall AND bulletproof!
- rocjoe71, on 10/12/2007, -0/+23...Resveratrol lets you run a little longer/faster? PFFT!
- DatDudeWiggs, on 10/12/2007, -5/+5Wouldn't it just be easier to bottle up Chuck Norris' sweat and distribute that?
- Lahonda, on 10/12/2007, -5/+3Chuck Norris would eat the mice and kick ALL our asses!
- vandread, on 10/12/2007, -5/+3I'm still trying to bottle his tears, the cure for cancer will make me millions, if only the bastard would cry once and a while...
- Lahonda, on 10/12/2007, -5/+3Chuck Norris doesn't cry, he makes it rain!
- Jwoey, on 10/12/2007, -3/+9stop stop stop stop stop stop with the chuck norris jokes.
- Kemo, on 10/12/2007, -4/+2A drug that can make you into a Superhuman? I thought that was Cocaine & Crystal Meth? hahaha!
- jasoninoakland, on 10/12/2007, -1/+1Not true about breast cancer. Research has shown that resveratrol is similar in structure to diethylstilbestrol, a synthetic estrogen, which is a potential breast cancer potentiator. But compounds similar in molecular structure can often have widely different biological effects, Other studies have shown resveratrol to inhibit cancer metastasis.
While superhuman doses like the test mice receive is unrealistic for most of us, a small dose, either by drinking pinot noir from a cool, moist region like Bordeaux or Willamette Valley (resveratrol is produced in response to mold attack), or taking a supplement, might be helpful.
More on studies of its effect on the longevity of other animals:
http://hubpages.com/hub/Resveratrol - philforhumanity, on 10/12/2007, -0/+6What if someone with MS takes it? Would it help/hurt?
- Langford, on 10/12/2007, -1/+5Only real way to find out would be to try it. Just speculating though, it might speed it up.
- billlyboobs34, on 10/12/2007, -0/+4Resveratrol, is an antioxidant. It really shouldn't have any negative affects on MS. As far as I can tell though, there has been no study to see the effects if any on MS (good or bad).
- Langford, on 10/12/2007, -0/+3It all depends on how the drug really works. Is it speeding up just repair, or cellular functions in general? If MS is caused by the body's immune system attacking myelin, then the drug might speed that process. It's still may be a race between MS and remyelination, but accelerated.
- billlyboobs34, on 10/12/2007, -1/+1That's pure speculation. There is no proof that it "speeds up" anything at all (besides mitochondria duplication). Energy generation in improved simply because of increased mitochondria number.
Resveratrol is commonly used to protect against degenerative disorders in studies... - Langford, on 10/12/2007, -0/+1Yeah, it was speculation. It certainly merits research, especially if it's good against other disorders.
- Corvidae, on 10/12/2007, -0/+1Last I heard MS was caused by your own immune system attacking the nerves thinking they were infected or foreign. No idea how this stuff would help or hurt the situation, it'd be generally dangerous to find out though.
- DeusMachinae, on 10/12/2007, -1/+1I'm surprised you're not spelling it M$
- Horseshoe, on 10/12/2007, -0/+3Hmmm...
2000mg = 2 grams
Polygonum cuspidatum extract (200:1), 50% resveratrol, powder 50g
50/2 =25g of pure stuff
25g/2 = 12.5 doses...
About 12 doses for $65 here:
http://www.shfnatural.com/Merchant2/merchant.mvc?Screen=PROD&Product_Code=99&Category_Code=
Now live long, and prosper!
(ok can anybody beat that deal?) - Lahonda, on 10/12/2007, -1/+5Well... I'm jush fine after 40 bottles of "peno newr" and my reshervshtrol levels 'r peakin' through the roof!
- crcurran, on 10/12/2007, -2/+3Mmmmm drugs.
- kragg, on 10/12/2007, -1/+0Eh resveratrol has been consumed for thousands of years just not in the doses given to these mice.
- davidlow, on 10/12/2007, -1/+8Resveratrol is not a drug. It is a component of some common foods, mainly grape skins, peanuts, blueberries and cranberries. It's not made in a lab, but extracted from foods and sold over the counter as a supplement. When red wine is fermented it still has its grape skins (unlike white wine), so there are significant levels of resveratrol in red wine. Muscadine red wine has 10 times more than other red wines (40 milligrams per liter).
Since mankind has been drinking red wine for more than a few days now, resveratrol is definitely not a *new* wonder drug. Remember all those studies about how red wine decrease bad things and increases good things (I'm summarizing)? Like in France? Well, those stories are related to this story.
http://en.wikipedia.org/wiki/Resveratrol- glmory, on 10/12/2007, -1/+4"Resveratrol is not a drug. It is a component of some common foods"
by definition it is a drug every bit as much as Asprin, or pot. The fact plants make it is irrelevant.
Also, there is a big difference in the dose. They are giving the mice the equivalent of a human drinking a few hundred glasses of wine. This means both its possible natural sources give you too little to be of use, and its possible that humans have bad side effects from taking enough to effect us. Just because its safe to take a small dose, does not mean its safe to take a big one. Botox is probably the best example of this. It is one of the more deadly poisons, yet rather safe in a doctors office in tiny doses.
That said, within a year or two we will have a much better idea, this may actually turn out to be one of the bigger discoveries of recent years... - davidlow, on 10/12/2007, -0/+3@glmory, Thank you. I stand corrected. By one of the many definitions of the word 'drug', resveratrol is definitely a drug; just like water, cod liver oil, and oxygen.
- glmory, on 10/12/2007, -1/+4"Resveratrol is not a drug. It is a component of some common foods"
- Lahonda, on 10/12/2007, -5/+6Anything to help the French live longer can't be good!
- dag27, on 10/12/2007, -3/+1I guess nobody is perfect. My wife is French but at least she's not a bigot.
- billlyboobs34, on 10/12/2007, -2/+2If she has a maid outfit I will be over in 10 minutes...
- Jcrizzle, on 10/12/2007, -0/+0seems like this effect could be accomplished with meds already on the market:
dextro-amphetamine for the increased energy and endurance
marinol for appetite stimulation
valium, xanax, or ativan if needed for possible anxiety caused by amphetamines
inderal (or any beta blocker) to lower your heart rate
and maybe a sleep aid as well.
but...good luck convincing a doctor to write you scripts for that many controlled substances ;-) - Neem, on 10/12/2007, -0/+6Reading this article brings me back to the discovery of statins ( lawlz firefox marks statins as misspelled, it also marks "firefox"-one word, as misspelled but I guess its right to do so, anyway I diverge ). Remember the good time when statins were the new wonder drug that were going to free us all from the evils of cholesterol without side-effects ? Then livers started to fail after prolonged use.
I thank science and common sense every day that my doctor told me to get off my lazy ass and run a mile every other day instead of writing me a prescription.- glmory, on 10/12/2007, -0/+3yeah, this is a mouse study, it is very promising, but hardly conclusive. I wouldn't start taking it until some double blinded human studies have been done.
- billlyboobs34, on 10/12/2007, -1/+0umm dude human lifespan is too long
- Smeed, on 10/12/2007, -4/+1They are called roids...
- skjalff, on 10/12/2007, -0/+6...superpowers drug that you can just rub in your skin? you'd think it would be something you had to free-base!..
- billlyboobs34, on 10/12/2007, -2/+0You still have to make sure it doesn't go through isomerisation to the trans form...
- MatTipton, on 10/12/2007, -0/+1This may have benifits for humans but most likely not to the same extent that you will see in lab mice. Lots of things have been shown to increase endurance in lab mice... like milk for instance.
- billlyboobs34, on 10/12/2007, -1/+0What about using female mice to increase male mouse endurance...
- Bullsnot, on 10/12/2007, -2/+1The secret of NIHM
- Lahonda, on 10/12/2007, -2/+1You're right! ***** it... after all this wine and steroids, I've determined that I just want to be a "Bad-ass Rat"!
- billlyboobs34, on 10/12/2007, -2/+0Now teach the mouse to inject itself with steroids like we have to. What a pain in the ass (literally).
- ajakz, on 10/12/2007, -0/+1I've been saying for years we need an all drug driven super Olympics. Guaranteed there will be volunteers,
- billlyboobs34, on 10/12/2007, -1/+0It's already drug driven...
If all drugs were allowed I would love to see that.
- billlyboobs34, on 10/12/2007, -1/+0It's already drug driven...
- Horseshoe, on 10/12/2007, -0/+3Ok I just beat my other price by looking around...and checked my numbers against the scientists (you know mg per kilogram stuff)
here's the cheapest I have found so far:
So I found 1Kg of stuff containing 50% Resveratrol for $175
What does this mean? Well it depends on which scientist you get the numbers from, so here are both:
The article says :
"Dr. Sinclair dosed his mice daily with 22 milligrams of resveratrol for each kilogram of weight, and Dr. Auwerx used up to 400 milligrams. No one could drink enough red wine to obtain such doses."
So if you buy the 1Kg of stuff in the link here: (http://www.nutrimart.com)
here's what you get:
(using DR. Sinclair's dosage)
For a 200 pound person
The dosage would be 1.98 grams a day (not milligrams, but Grams!)
You would get 252 dosages, at $0.69 a dosage
(using Dr. Auwerx dosage)
For a 200 pound person
The dosage would be 36 grams a day (36 grams = 0.0793664144 pounds)
You would get 13.88 dosages, at $12.60 a dosage- Horseshoe, on 10/12/2007, -0/+1oops that was..
http://www.nutrimart.com/bulkraw.htm - noisebleed, on 10/12/2007, -0/+0It looks like the minimum order is 25Kg.. or am I just not seeing where a 1Kg package is listed?
- Horseshoe, on 10/12/2007, -0/+1oops that was..
- Pissoff, on 10/12/2007, -0/+1So wouldn't the best thing be just eating a lot of fresh red grapes?
- Horseshoe, on 10/12/2007, -0/+1The stuff in grapes are measured in MICRO-grams...
you need a ***** load of grapes a day to get it all...
- Horseshoe, on 10/12/2007, -0/+1The stuff in grapes are measured in MICRO-grams...
- SanTe, on 10/12/2007, -1/+2I just can't read "Resveratrol" without hearing "Reversitall" in my head, which is what people will jokingly call it. Naming it "Resveratrol" has got to be the biggest dropped ball in marketing history. Unless that's the scientific community's name for it... then Pfizer or some other pharma company still has a chance. :)
- Lahonda, on 10/12/2007, -1/+2If the drug companies wanted us to live, they'da discovered "cures" already. Tres strange that we all just keep getting sick with all the good ol' diseases...
-
Show 51 - 58 of 58 discussions
Browsing Digg on your phone just got easier with our enhancements to the 
© Digg Inc. 2008 —
Content posted by